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Originally posted on STH Journal Club:
Myburgh JA, Finfer S, Bellomo R et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. New England Journal of Medicine 2012; 367: 1901-1911.
RHH Journal Club. November 22nd, 2012. Dr Balaji Kasa
No free full-text available
To evaluate the safety and efficacy of 6% HES (130/0.4) in 0.9% saline as compared to 0.9% saline alone for fluid resuscitation in ICU.
Type of Study: Multicentre, Prospective, Blinded, Parallel group, Randomised controlled trial
7000 patients from 32 hospitals in Australia and New Zealand, 18 years or older eligible for admission to ICU and who met the criteria for fluid resuscitation
Exclusions: more than 1000mls of HES is administered to patient before screening, those with impending or current dialysis dependent renal failure and those with intracranial haemorrhage on CT scan.
HES(130/0.4) in 0.9% saline or 0.9% saline
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