Early NA in sepsis

Early vs delayed administration of norepinephrine in patients with septic shock. Bai et al. Critical Care 2014, 18:532

Appraisal by Dr. Peter Tsim.  Read more »

Procalcitonin – D Dimer for sepsis?

The following discussion is taken from a presentation given at JC by Dr Dave Hewson, ST5 Anaesthetics, in which he explores the utility of PROCALCITONIN: Read more »

Proning – Is it worth the hassle?

Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis

Appraiser: Dr Andrew Langton Read more »

Sleep like a baby?

The effect of a multicomponent multidisciplinary bundle of interventions on sleep and delirium in medical and surgical intensive care patients.
Patel J, Baldwin J, Bunting P, Laha S
Anaesthesia. 2014 Jun;69(6):540-9

Read more »

Trop tops?

Role of troponin in patients with chronic kidney disease and suspected acute coronary syndrome: a systematic review.

Sylvie R. Stacy, et al

Ann Intern Med. Published online 12 August 2014 doi:10.7326/M14-0746 Read more »

Esmolol in septic shock

Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.

Morelli A1 et al

JAMA. 2013 Oct 23;310(16):1683-91. doi: 10.1001/jama.2013.278477.

STUDY APPRAISER: Dr David Smith Read more »

Hear no Evil?

The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients

Van Rompaey et al. Critical Care 2012, 16:R73. (full text available)


Read more »

Extubation to NIPPV

Non-invasive ventilation immediately after extubation improves weaning outcome after acute respiratory failure: a randomized controlled trial.

Ornico SR, Lobo SM, Sanches HS, Deberaldini M, Tófoli LT, Vidal AM, Schettino GP, Amato MB, Carvalho CR, Barbas CS. Crit Care. 2013 Mar 4;17(2):R39. (full text available)

Read more »


Lower Tidal Volume Strategy (3ml/kg) Combined with Extracorporeal CO2 Removal Versus ‘Conventional’ Protective Ventilation (6 ml/kg) in Severe ARDS (Bein et al)

Intensive Care Med Vol 39, Issue 5, pg 847–856, May 2013

QMC AICU Journal Club, April 2013.

Dr Amit Pancholi 


Read more »

Salt is better than sugar


Here’s a taster of the excellent stuff available over at sthjournalclub. Go & follow this blog now!

Originally posted on STH Journal Club:

Myburgh JA, Finfer S, Bellomo R et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. New England Journal of Medicine 2012; 367: 1901-1911.

RHH Journal Club. November 22nd, 2012. Dr Balaji Kasa

No free full-text available

To evaluate the safety and efficacy of 6% HES (130/0.4) in 0.9% saline as compared to 0.9% saline alone for fluid resuscitation in ICU.

Type of Study: Multicentre, Prospective, Blinded, Parallel group, Randomised controlled trial



7000 patients from 32 hospitals in Australia and New Zealand, 18 years or older eligible for admission to ICU and who met the criteria for fluid resuscitation

Exclusions: more than 1000mls of HES is administered to patient before screening, those with impending or current dialysis dependent renal failure and those with intracranial haemorrhage on CT scan.

Intervention /Control

HES(130/0.4) in 0.9% saline or 0.9% saline



View original 115 more words


Get every new post delivered to your Inbox.

Join 568 other followers