Archive for July, 2008|Monthly archive page

Physiological Effects of Hyperchloraemia and Acidosis

Physiological Effects of Hyperchloraemia and Acidosis. Handy, JM & Soni, N. British Journal of Anaesthesia. 2008, 101(2):141-50.

Useful or interesting review articles & editorials will be flagged on the site from time to time. This is an interesting physiology review article challanging a few widely held views…..

Dr Dan Harvey

Non Invasive Ventilation in Acute Cardiogenic Pulmonary Edema

Non-Invasive Ventilation in Acute cardiogenic Pulmonary Edema. Gray, A et al. NEJM, 2008. 359: 142-51. (or here on pubmed)

The “3 interventions in Cardiogenic Pulmonary oedema trial (3CPO)” trail was a multicentre, open, prospective randomised trial. 1069 patients were randomised over 4 years in 23 different centres in the UK. 3 treatment arms, all targeted to achieve sats >92%. 1: Oxygen, 2: CPAP 5-15cmH20 and 3: BiPAP 8-20/4-10.

Previous trials have suggested a reduction in intubation rates and a mortality benefit for CPAP or NIV, but some concerns over an increased MI rate with NIV.

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Podcasts for Intensive Care

Although this is not directly related to a specific article (sorry Dan) I thought this would be a good medium to recommend the podcasts from the Critical Care Society and NEJM. You can download them for FREE via Itunes. I have then burned them onto CDs to listen to them in the car on the way to work.

I wonder if Dan would let other people recommend similar methods of keeping up to date.

Mark Simmonds