Archive for February, 2009|Monthly archive page

Dexmedetomidine vs Midazolam

Dexmedetomidine vs Midazola for sedation of critically ill patients : A randomised control trial. Riker, R. et al. JAMA 301 (5) 489-99.

This prospective, double blind, multicentred RCT compared the alpha agonist dexmedotomdine against midazolam. It was designed to assess safety & efficacy. A total of 375 patients expected to be ventilated for > 24hrs were randomised to either agent targeted to a RASS score of between -2 to +1. Primary outcome measure was period of time within target range, secondary end points included delirium scores & duration of ventilation Continue reading

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Management of Subarachnoid Heamorrhage

Management of aneurysmal subarachnoid heamorrhage. Dringer. M. Critical Care Medicine 37 (2) Feb 2009; 432-440.

A useful & comprehensive educational review article from CCM on the management of SAH, highlighted for interest. Unfortunately for copyright reasons we can’t provide a link to the pdf, but you can access it from the above link if you have an ATHENS account.

Early Mortality Prediction in Acute Pancreatitis

The early prediction of mortality in acute pancreatitis: a large population-based study. Wu Et al. Gut 2008; 57:1698-1703

Back after an extended Christmas break with thanks to Miss. Emma Collins for sharing this recent presentation from QMC’s journal club, a copy of which can be found in the blue box to the right.

This reterospective study used regression analysis to identify risk factors for early mortality within the first 24 hours of admission. The subsequent scoring system was compared against APACHE II and tested against the same database.

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